Fonts
Calibri. The nice happy new Microsoft font, it just looks so good for everything and would love to see a book published in this font. It's very readable.
Spacing
I think 1.5 spacing for each sentence should go nicely, i think because the book would be fairly word heavy, i think some nice spacing will make it easily readable.
These are obviously very basic suggestions, i just felt as though it would be a good startoff point for some discussion on the content layout

